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Helmanthiasis the helminth being a trematode flatworm of the genus Schistosoma, i. A biological assay that mimics a disease causative mechanism can be used to test the therapeutic activity of a candidate peptide.
The causative mechanism of many diseases is the over activity of a biological pathway. Similarly the causative mechanism of many diseases is the over production of a biological molecule. Conversely, the causative mechanism of many diseases is the under activity of a biological pathway.
Also similarly the causative mechanism of many diseases is the under production of a biological molecule. The object of the present invention is solved by the teaching of the independent claims.
Further advantageous features, aspects and details of the invention are evident from the dependent claims, the description, and the examples of the present application.
Also disclosed are pharmaceutical formulations preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation containing the inventive peptide. Cancer, tumors, proliferative diseases, malignancies and their metastases The term "cancer" as used herein refers also to tumors, proliferative diseases, malignancies and their metastases.
Infectious disease The immune system in higher vertebrates represents the first line of defense against various antigens that can enter the vertebrate body, including microorganisms such as bacteria, fungi and viruses that are the causative agents of Lesser sac cystic lymphangioma gastric outlet obstruction variety of diseases.
Despite large immunization programs, viral infections, such as influenza virus, human immunodeficiency virus "HIV"herpes simplex virus "HSV", type 1 or 2human papilloma virus "HPV", type 16 or 18human cytomegalovirus "HCMV" or human hepatitis B or C virus "HBV", Type B; "HCV", type C infections, remain a serious source of morbidity and mortality throughout the world and a significant cause of illness and death among people with immune-deficiency associated with aging or different clinical conditions.
Although antiviral chemotherapy with compounds such as amantadine and rimantadine have been shown to reduce the duration of symptoms of clinical infections i. New classes of antiviral agents designed to target particular viral proteins such as influenza neuraminidase are being developed.
However, the ability of viruses to mutate the target proteins represents an obstacle for effective treatment with molecules which selectively inhibit the function of specific viral polypeptides. Thus, there is need for new therapeutic strategies to prevent and treat viral infections.
Additionally, there is a need for new therapies for the prevention and treatment of bacterial infections, especially bacterial infections caused by multiple drug resistant bacteria.
Currently, bacterial infections are treated with various antibiotics. Although antibiotics have and can be effective in the treatment of various bacterial infections, there are a number of limitations to the effectiveness and safety of antibiotics.
For example, some individuals have an allergic reaction to certain antibiotics and other individuals suffer from serious side effects. Moreover, continued use of antibiotics for the treatment of bacterial infections contributes to formation of antibiotic-resistant strains of bacteria.
Prions are infectious agents which do not have a nucleic acid genome. It seems that a protein alone is the infectious agent. A prion has been defined as "small proteinaceous infectious particle which resists inactivation by procedures that modify nucleic acids".
The discovery that proteins alone can transmit an infectious disease came as a considerable surprise to the scientific community. Prion diseases are often called "transmissible spongiform encephalopathies", because of the post mortem appearance of the brain with large vacuoles in the cortex and cerebellum.
Probably most mammalian species develop these diseases. Prion diseases are a group of neurodegenerative disorders of humans and animals and the prion diseases can manifest as sporadic, genetic or infectious disorders.
Examples of prion diseases acquired by exogenous infection are bovine spongiform encephalitis BSE of cattle and the new variant of Creutzfeld-Jakob disease vCJD caused by BSE as well as scrapie of animals.
The name "prion" is used to describe the causative agents which underlie the transmissible spongiform encephalopathies. A prion is proposed to be a novel infectious particle that differs from viruses and viroids. It is composed solely of one unique protein that resists most inactivation procedures such as heat, radiation, and proteases.
The latter characteristic has led to the term protease-resistant isoform of the prion protein. The protease-resistant isoform has been proposed to slowly catalyze the conversion of the normal prion protein into the abnormal form.
The term "isoform" in the context of prions means two proteins with exactly the same amino acid sequence that can fold into molecules with dramatically different tertiary structures. As used herein the term "prion diseases" refers to transmissible spongiform encephalopathies.
Streptococcus pneumoniae infection Streptococcus pneumoniae, also known as pneumococcus, is an alpha-hemolytic diplococcus bacterium and a member of the genus Streptococcus that is often found in the noses and throats of healthy persons and is spread person-to-person through close contact.
Pneumococcus is a common cause of mild illnesses, such as sinus and ear infections, but also causes life-threatening infections such as pneumonia, meningitis, infections of the bloodstream, acute sinusitis, otitis media, osteomyelitis, septic arthritis, endocarditis, peritonitis, pericarditis, and brain abscess.
Many strains are resistant to antibiotics. Streptococcus pneumoniae is the most common cause of bacterial meningitis in adults and children, and is one of the top two isolates found in otitis media.
Pneumococcal pneumonia is more common in the very young and the very old. Pneumococcal disease occurs worldwide. Pneumococcal disease is more common in winter months and when respiratory viruses such as influenza are circulating.
Outbreaks of pneumococcal disease are not common but can occur in child care centers, nursing homes, or other institutions. In the United States, most deaths from pneumococcal disease occur in older adults, although in developing countries many children die of pneumococcal pneumonia.1.
Gastric outlet obstruction 2. Perforation 3. Carcinoma 4. Pancreatitis In a case of hypertrophic pyloric stenosis, the metabolic disturbance is: 1.
Respiratory alkalosis 2. Metabolic acidosis 3. Metabolic alkalosis with paradoxical aciduria 4. Metabolic alkalosis with alkaline urine A 25 year old office executive presents with. Search the history of over billion web pages on the Internet.
Fermer les suggestions. Transférer. Se connecter. malignant neoplasm of lesser curvature of stomach unspecified: malignant neoplasm of greater curvature of stomach unspecified: malignant neoplasm of other specified sites of stomach: malignant neoplasm of stomach unspecified site: malignant neoplasm of duodenum: malignant neoplasm of jejunum: malignant.
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